Naturalistic Entheogenics: Précis of Philosophy of Psychedelics
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Keywords

DMT
LSD
Ayahuasca
Mescaline
Psilocybin
Philosophy
Epistemology
Spirituality
Self-Representation
Psychedelics
Predictive Processing

How to Cite

Naturalistic Entheogenics: Précis of Philosophy of Psychedelics. (2022). Philosophy and the Mind Sciences, 3. https://doi.org/10.33735/phimisci.2022.9627

Abstract

In this précis I summarise the main ideas of my book Philosophy of Psychedelics. The book discusses philosophical issues arising from the therapeutic use of “classic” (serotonergic) psychedelic drugs such as psilocybin and LSD. The book is organised around what I call the Comforting Delusion Objection to psychedelic therapy: the concern that this novel and promising treatment relies essentially on the induction of non-naturalistic metaphysical beliefs, rendering it epistemically (and perhaps, therefore, ethically) objectionable. I begin the précis by summarizing material from chapters two and three of the book, which review evidence for the therapeutic efficacy of psychedelics, and the facts about their clinical use that prompt the Comforting Delusion Objection. I then summarize materials from chapters four and five of the book, which argue that psychedelic therapy works neither by experience-independent processes of neuroplasticity, nor by inducing non-naturalistic metaphysical ideations, but by altering mental representations of the self. Next, I summarise the specific, speculative account of how this might work that is developed in chapters six and seven of the book. This account is based on the predictive processing theory of brain function and the self-binding theory of self-representation. Chapters eight and nine of the book argue, on the basis of this account, that psychedelic therapy can have significant epistemic and spiritual benefits that are compatible with a naturalistic worldview. I summarize this material, and then, finally, the overall conclusions about psychedelic therapy drawn in the tenth and final chapter of the book.

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References

Aday, J. S., Mitzkovitz, C. M., Bloesch, E. K., Davoli, C. C., & Davis, A. K. (2020). Long-term effects of psychedelic drugs: A systematic review. Neuroscience & Biobehavioral Reviews, 113, 179–189. https://doi.org/10.1016/j.neubiorev.2020.03.017

Albahari, M. (2006). Analytical Buddhism: The Two-tiered Illusion of Self. Palgrave.

Baillie, J. (2020). The recognition of nothingness. Philosophical Studies, 177(9), 2585–2603. https://doi.org/10.1007/s11098-019-01329-6

Bogenschutz, M. P., Podrebarac, S. K., Duane, J. H., Amegadzie, S. S., Malone, T. C., Owens, L. T., Ross, S., & Mennenga, S.E. (2018). Clinical interpretations of patient experience in a trial of psilocybin-assisted psychotherapy for alcohol use disorder. Frontiers in Pharmacology, 9. https://doi.org/10.3389/fphar.2018.00100

Bortolotti, L. (2015). The epistemic innocence of motivated delusions. Consciousness and Cognition, 33, 490–499. https://doi.org/10.1016/j.concog.2014.10.005

Bortolotti, L. (2020). The Epistemic Innocence of Irrational Beliefs. Oxford University Press.

Breeksema, J. J., Niemeijer, A. R., Krediet, E., Vermetten, E., & Schoevers, R. A. (2020). Psychedelic Treatments for Psychiatric Disorders: A Systematic Review and Thematic Synthesis of Patient Experiences in Qualitative Studies. CNS Drugs, 34(9), 925–946. https://doi.org/10.1007/s40263-020-00748-y

Carhart-Harris, R. L. (2019). How do psychedelics work? Current Opinion in Psychiatry, 32(1), 16–21. https://doi.org/10.1097/YCO.0000000000000467

Carhart-Harris, R. L., & Friston, K. J. (2019). REBUS and the anarchic brain: Toward a unified model of the brain action of psychedelics. Pharmacological Reviews, 71(3), 316–344. https://doi.org/10.1124/pr.118.017160

Carhart-Harris, R. L., Roseman, L., Bolstridge, M., Demetriou, L., Pannekoek, J. N., Wall, M. B., Tanner, M., Kaelen, M. McGonigle, J., Murphy, K., Leech, R., Curran, H. V., & Nutt, D. J. (2017). Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Scientific Reports, 7(1), 13187. https://doi.org/10.1038/s41598-017-13282-7

Conee, E. (1994). Phenomenal knowledge. Australasian Journal of Philosophy, 72(2), 136–150. https://doi.org/10.1080/00048409412345971

Davey, C. G., Pujol, J., & Harrison, B. J. (2016). Mapping the self in the brain’s default mode network. NeuroImage, 132, 390–397. https://doi.org/10.1016/j.neuroimage.2016.02.022

Davis, A. K., Barrett, F. S., & Griffiths, R. R. (2020). Psychological flexibility mediates the relations between acute psychedelic effects and subjective decreases in depression and anxiety. Journal of Contextual Behavioral Science, 15, 39–45. https://doi.org/10.1016/j.jcbs.2019.11.004

Dennett, D. C. (1992). The self as the center of narrative gravity. In F. Kessel, P. Cole and D. Johnson (Eds.), Self and Consciousness: Multiple Perspectives (pp. 275–288). Psychology Press.

Durr, R. A. (1971). Poetic Vision and the Psychedelic Experience. Syracuse University Press.

Flanagan, O., & Graham, G. (2017). Truth and sanity: Positive illusions, spiritual delusions, and metaphysical hallucinations. In J. Poland & S, Tekin (Eds.). Extraordinary Science and Psychiatry: Responses to the Crisis in Mental Health Research (pp. 293–313). MIT Press. https://doi.org/10.7551/mitpress/9780262035484.003.0013

Gerrans, P. (2014). The Measure of Madness: Philosophy of Mind, Cognitive Neuroscience, and Delusional Thought. MIT Press.

González, D., Cantillo, J., Pérez, I., Farré, M., Feilding, A., Obiols, J. E., & Bouso, J. C. (2020). Therapeutic potential of ayahuasca in grief: A prospective, observational study. Psychopharmacology, 237(4), 1171–1182. https://doi.org/10.1007/s00213-019-05446-2

Griffiths, R. R., Johnson,M.W., Carducci,M. A., Umbricht, A., Richards,W. A., Richards, B. D., Cosimano,M. P., & Klinedinst, M. A. (2016). Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of Psychopharmacology, 30(12), 1181–1197. https://doi.org/10.1177/0269881116675513

Griffiths, R. R., Richards, W. A., McCann, U., & Jesse, R. (2006). Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology, 187(3), 268–283. https://doi.org/10.1007/s00213-006-0457-5

Griffiths, R., Richards, W., Johnson, 956 M., McCann, U., & Jesse, R. (2008). Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. Journal of Psychopharmacology, 22(6), 621–632. https://doi.org/10.1177/0269881108094300

Grob, C. S. (2007). The use of psilocybin in patients with advanced cancer and existential anxiety. In M.Winkelman and T. B. Roberts (Eds.), Psychedelic Medicine: New Evidence for Hallucinogenic Substances as Treatments (pp. 205–216). Praeger Publishers.

Heuschkel, K., & Kuypers, K. P. C. (2020). Depression, mindfulness, and psilocybin: Possible complementary effects of mindfulness meditation and psilocybin in the treatment of depression. A review. Frontiers in Psychiatry, 11. https://doi.org/10.3389/fpsyt.2020.00224

Hohwy, J. (2013). The Predictive Mind. Oxford University Press.

Horst, S. (2009). Naturalisms in philosophy of mind. Philosophy Compass, 4(1), 219–254. https://doi.org/10.1111/j.1747-9991.2008.00191.x

James, E., Robertshaw, T. L., Hoskins, M., & Sessa, B. (2020). Psilocybin occasioned mystical-type experiences. Human Psychopharmacology: Clinical and Experimental, 35(5), e2742. https://doi.org/10.1002/hup.2742

Jopling, D. A. (2001). Placebo insight: The rationality of insight-oriented psychotherapy. Journal of Clinical Psychology, 57(1), 19–36. https://doi.org/10.1002/1097-4679(200101)57:1%3C19::AID-JCLP4%3E3.0.CO;2-Z

Lavazza, A. (2017). Ways of being well: Realistic and unrealistic well-being. In L. Taddio and K. W. Molin (Eds.), New Perspectives on Realism (pp. 237–252). Mimesis International.

Letheby, C. (2020). Being for no-one: Psychedelic experience and minimal subjectivity. Philosophy and the Mind Sciences, 1(I), 1–26. https://doi.org/10.33735/phimisci.2020.I.47

Letheby, C. (2021). Philosophy of Psychedelics. Oxford University Press.

Letheby, C., & Gerrans, P. (2017). Self unbound: Ego dissolution in psychedelic experience. Neuroscience of Consciousness, 2017(1). https://doi.org/10.1093/nc/nix016

Ly, C., Greb, A. C., Cameron, L. P., Wong, J. M., Barragan, E. V., Wilson, P. C., Burbach, K. F., Soltanzadeh Zarandi, S., Sood, A., Paddy, M. R., Duim, W. C., Dennis, M. Y., McAllister, A. K., Ori-McKenney, K. M., Gray, J. A., & Olson, D.E. (2018). Psychedelics promote structural and functional neural plasticity. Cell Reports, 23(11), 3170–3182. https://doi.org/10.1016/j.celrep.2018.05.022

Madsen, M. K., Fisher, P. M., Stenbæk, D. S., Kristiansen, S., Burmester, D., Lehel, S., Páleníček, T., Kuchař, M., Svarer, C., Ozenne, B., & Knudsen, G. M. (2020). A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding. European Neuropsychopharmacology, 33, 71–80. https://doi.org/10.1016/j.euroneuro.2020.02.001

Malone, T. C., Mennenga, S. E., Guss, J., Podrebarac, S. K., Owens, L. T., Bossis, A. P., Belser, A. B., Agin-Liebes, G., Bogenschutz, M. P., & Ross, S. (2018). Individual experiences in four cancer patients following psilocybin-assisted psychotherapy. Frontiers in Pharmacology, 9. https://doi.org/10.3389/fphar.2018.00256

Metzinger, T. (2003). Being No One: The Self-Model Theory of Subjectivity. MIT Press.

Metzinger, T. (2013). Spirituality and Intellectual Honesty. Self-published manuscript. https://philarchive.org/rec/METSAI

Metzinger, T. (2014). How does the brain encode epistemic reliability? Perceptual presence, phenomenal transparency, and counterfactual richness. Cognitive Neuroscience, 5(2), 122–124. https://doi.org/10.1080/17588928.2014.905519

Mian, M. N., Altman, B. R., & Earleywine, M. (2020). Ayahuasca’s antidepressant effects covary with behavioral activation as well as mindfulness. Journal of Psychoactive Drugs, 52(2), 130–137. https://doi.org/10.1080/02791072.2019.1674428

Nichols, D., Johnson, M., & Nichols, C. (2017). Psychedelics as medicines: An emerging new paradigm. Clinical Pharmacology & Therapeutics, 101(2), 209–219. https://doi.org/10.1002/cpt.557

Noorani, T., Garcia-Romeu, A., Swift, T. C., Griffiths, R. R., & Johnson, M. W. (2018). Psychedelic therapy for smoking cessation: Qualitative analysis of participant accounts. Journal of Psychopharmacology, 32(7), 756–769. https://doi.org/10.1177/0269881118780612

Pavese, C. (2021). Knowledge how. In E. Zalta (Ed.) The Stanford Encyclopedia of Philosophy. https://plato.stanford.edu/archives/sum2021/entries/knowledge-how/

Pollan, M. (2015). The trip treatment. The New Yorker. http://www.newyorker.com/magazine/2015/02/09/trip-treatment

Pollan, M. (2018). How to Change Your Mind: The New Science Of Psychedelics. Penguin Books.

Revonsuo, A. (2006). Inner Presence: Consciousness as a Biological Phenomenon. MIT Press.

Ross, S., Bossis, A., Guss, J., Agin-Liebes, G., Malone, T., Cohen, B., Mennenga, S. E., Belser, A., Kalliontzi, K., Babb, J., Su, Z., Corby, P., & Schmidt, B. L. (2016). Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: A randomized controlled trial. Journal of Psychopharmacology, 30(12), 1165–1180. https://doi.org/10.1177/0269881116675512

Russell, B. (1910). Knowledge by acquaintance and knowledge by description. Proceedings of the Aristotelian Society, 11, 108–128. https://www.jstor.org/stable/4543805

Seeley, W.W. (2019). The salience network: A neural system for perceiving and responding to homeostatic demands. Journal of Neuroscience, 39(50), 9878–9882. https://doi.org/10.1523/JNEUROSCI.1138-17.2019

Sessa, B. (2012). The Psychedelic Renaissance: Reassessing the Role of Psychedelic Drugs in 21st Century Psychiatry and Society. Muswell Hill Press.

Shanon, B. (2010). The epistemics of ayahuasca visions. Phenomenology and the Cognitive Sciences, 9(2), 263–280. https://doi.org/10.1007/s11097-010-9161-3

Smith, H. (2003). Cleansing the Doors of Perception: the Religious Significance of Entheogenic Plants and Chemicals. Sentient Publications.

Stone, J. A. (2012). Spirituality for naturalists. Zygon: Journal of Religion and Science, 47(3), 481–500. https://doi.org/10.1111/j.1467-9744.2012.01279.x

Sui, J., & Gu, X. (2017). Self as object: Emerging trends in self research. Trends in Neurosciences, 40(11), 643–653. https://doi.org/10.1016/j.tins.2017.09.002

Sui, J., & Humphreys, G. W. (2015). The integrative self: How self-reference integrates perception and memory. Trends in Cognitive Sciences, 19(12), 719–728. https://doi.org/10.1016/j.tics.2015.08.015

Swift, T. C., Belser, A. B., Agin-Liebes, G., Devenot, N., Terrana, S., Friedman, H. L., Guss, J., Bossis, A. P., & Ross, S. (2017). Cancer at the dinner table: Experiences of psilocybin-assisted psychotherapy for the treatment of cancer-related distress. Journal of Humanistic Psychology, 57(5), 488–519. https://doi.org/10.1177/0022167817715966

Watts, R., Day, C., Krzanowski, J., Nutt, D., & Carhart-Harris, R. (2017). Patients’ accounts of increased “connectedness” and “acceptance” after psilocybin for treatment-resistant depression. Journal of Humanistic Psychology, 57(5), 520–564. https://doi.org/10.1177/0022167817709585

Yang, C., Shirayama, Y., Zhang, J., Ren, Q., Yao, W., Ma, M., Dong, C., & Hashimoto, K. (2015). R-ketamine: A rapid onset and sustained antidepressant without psychotomimetic side effects. Translational Psychiatry, 5(9), e632–e632. https://doi.org/10.1038/tp.2015.136

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